Therapeutic controlled release
Micelle based therapeutics dissolution for local release.
We are using amphiphilic copolymer polyethers as structures that self assemble around body temperature. We have probed release of antibiotics and antimicrobials, chemotherapeutics, and other probiotics, embedded in these structures. We have an NIH proposal in review and a large review paper coming out
Injectable self-assembling gels
Relating to antibiotics, the flooding of a locally infected area is applicable to both joint replacement, general sepsis, and perhaps linked with surface infections arising from limb extension procedures. Since micelle-based self assembling gels are a platform technology, swapping out antibiotics for another therapeutic might be just as relevant. We are considering other disease fronts and delivering other payloads. Sharon Song has been considering chemotherpeutics with in vitro testing and there may be other areas where infection control is also needed.